In July 2004, returning after a 13 year absence, the Salvation's Answer-era re-formed as Against Nature and began writing and rehearsing new music. The fun quickly turned into a serious artistic commitment, and the band recorded two discs' worth of music, "Appease" and "Panoply," at one studio session in May 2005. On a creative drive that has not subsided to this day, the band recorded their next three discs in quick succession: "Safe Dissonance," "Ghosting," and "Leer," all released in 2006.

Against Nature has played the Templars of Doom II festival in Indianapolis, the Doom Shall Rise IV festival in Germany, the Stoner Hands of Doom VII festival in Mesa, AZ, the Doomed to Fall festival in San Antonio, TX in 2006, and the Doom or Be Doomed festival (hosted and organized by John Brenner and Josh Hart) in Baltimore, MD in 2007.